|Full Name||protein kinase, DNA-activated, catalytic polypeptide|
|Product Description||Rabbit polyclonal antibody to DNA-PKcs (protein kinase, DNA-activated, catalytic polypeptide)|
|Background||The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM]|
|Synonyms||DNA-PKcs antibody, DNAPK antibody, DNPK1 antibody, HYRC antibody, HYRC1 antibody, XRCC7 antibody, p350 antibody, PRKDC antibody, p460 antibody, "hyper-radiosensitivity of murine scid mutation, complementing 1 antibody", DNA-PK catalytic subunit antibody, DNA-dependent protein kinase catalytic subunit antibody, "protein kinase, DNA-activated, catalytic polypeptide antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DNA-PKcs. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Chicken|
|Predict Reactivity Note||Mouse (83%), Dog (83%), Chicken (90%)|