|Full Name||ligase IV, DNA, ATP-dependent|
|Product Description||Rabbit Polyclonal antibody to DNA ligase IV (ligase IV, DNA, ATP-dependent)|
|Background||The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]|
|Synonyms||LIG4 antibody, DNA ligase 4 antibody, polynucleotide ligase antibody, sealase antibody, DNA repair enzyme antibody, DNA ligase IV antibody, polydeoxyribonucleotide synthase [ATP] 4 antibody, DNA joinase antibody, "ligase IV, DNA, ATP-dependent antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase IV. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Sheep (83%), Bovine (86%)|