|Full Name||polymerase (DNA directed) iota|
|Product Description||Rabbit Polyclonal antibody to DNA polymerase iota (polymerase (DNA directed) iota)|
|Background||Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. |
|Synonyms||RAD30B antibody, RAD3OB antibody, POLI antibody, "polymerase (DNA-directed), iota antibody", RAD30 homolog B antibody, eta2 antibody, DNA polymerase iota antibody, polymerase (DNA directed) iota antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DNA polymerase iota. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (85%), Rat (85%), Chimpanzee (98%), Bovine (89%)|