|Full Name||DNA (cytosine-5-)-methyltransferase 1|
|Product Description||Goat polyclonal antibody to DNMT1|
|Background||Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
|Synonyms||FLJ16293, CXXC9, DNA methyltransferase 1, DNA methyltransferase1, DNA (cytosine5)methyltransferase1, DNMT, DNMT1, DNA (cytosine-5-)-methyltransferase 1, DNA (cytosine5)methyltransferase 1, MCMT, MGC104992, AIM|
|Specificity||This antibody is specific for DNMT1.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Bovine, Pig|