|Full Name||deoxyribonuclease I|
|Product Description||Rabbit Polyclonal antibody to DNase I (deoxyribonuclease I)|
|Background||This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]|
|Synonyms||DKFZp686H0155 antibody, DNL1 antibody, DRNI antibody, FLJ38093 antibody, FLJ44902 antibody, DNASE1 antibody, Dornase alfa antibody, deoxyribonuclease-1 antibody, "DNase I, lysosomal antibody", human urine deoxyribonuclease I antibody, deoxyribonuclease I antibody|
|Cellular Localization||Secreted , Nucleus envelope |
|Immunogen||Recombinant protein corresponding to human DNase I.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Dog (81%)|