|Full Name||docking protein 1, 62kDa (downstream of tyrosine kinase 1)|
|Product Description||Rabbit Polyclonal antibody to DOK1 (docking protein 1, 62kDa (downstream of tyrosine kinase 1))|
|Background|| Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq]|
|Synonyms||MGC117395 antibody, MGC138860 antibody, P62DOK antibody, DOK1 antibody, Downstream of tyrosine kinase 1 antibody, docking protein 1 (downstream of tyrosine kinase 1) antibody, pp62 antibody, docking protein 1 antibody, p62(dok) antibody, "docking protein 1, 62kDa (downstream of tyrosine kinase 1) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DOK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (88%), Pig (92%), Bovine (92%)|