|Full Name||D4, zinc and double PHD fingers family 1|
|Product Description||Rabbit Polyclonal antibody to DPF1 (D4, zinc and double PHD fingers family 1)|
|Background||May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.|
|Synonyms||BAF45b antibody, MGC150428 antibody, MGC150429 antibody, NEUD4 antibody, neuro-d4 antibody, DPF1 antibody, neuro-d4 homolog antibody, zinc finger protein neuro-d4 antibody, BRG1-associated factor 45B antibody, "D4, zinc and double PHD fingers family 1 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DPF1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Zebrafish (84%), Bovine (99%)|