|Full Name||Down syndrome cell adhesion molecule|
|Product Description||Goat polyclonal antibody to DSCAM|
|Background||Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. |
|Synonyms||human CHD252 down syndrome cell adhesion molecule, CHD242, CHD252, Down syndrome cell adhesion molecule, DSCAM, CHD2-52, CHD2-42, human CHD2-52 down syndrome cell adhesion molecule|
|Cellular Localization||Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. |
|Specificity||This antibody is specific for DSCAM.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog|