|Full Name||dual specificity phosphatase 10|
|Product Description||Rabbit Polyclonal antibody to DUSP10 (dual specificity phosphatase 10)|
|Background||Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||MKP-5 antibody, MKP5 antibody, DUSP10 antibody, map kinase phosphatase 5 antibody, serine/threonine specific protein phosphatase antibody, mitogen-activated protein kinase phosphatase 5 antibody, dual specificity protein phosphatase 10 antibody, dual specificity phosphatase MKP-5 antibody, dual specificity phosphatase 10 antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DUSP10. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Chicken (84%), Rhesus Monkey (98%), Bovine (95%)|