|Full Name||dual specificity phosphatase 12|
|Product Description||Rabbit Polyclonal antibody to DUSP12 (dual specificity phosphatase 12)|
|Background||The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq]|
|Synonyms||DUSP1 antibody, YVH1 antibody, DUSP12 antibody, dual specificity tyrosine phosphatase YVH1 antibody, serine/threonine specific protein phosphatase antibody, YVH1 protein-tyrosine phosphatase ortholog antibody, dual specificity protein phosphatase 12 antibody, dual specificity phosphatase 12 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DUSP12. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (87%), Rat (88%)|