|Full Name||dual specificity phosphatase 14|
|Product Description||Rabbit polyclonal antibody to DUSP14 (dual specificity phosphatase 14)|
|Background||In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM]|
|Synonyms||MKP-L antibody, MKP6 antibody, DUSP14 antibody, dual specificity protein phosphatase 14 antibody, MAP kinase phosphatase 6 antibody, MKP-6 antibody, MKP-1-like protein tyrosine phosphatase antibody, MKP-1 like protein tyrosine phosphatase antibody, mitogen-activated protein kinase phosphatase 6 antibody, dual specificity phosphatase 14 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DUSP14. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Rhesus Monkey (100%)|