|Full Name||dual specificity phosphatase 2|
|Product Description||Rabbit Polyclonal antibody to DUSP2/PAC1 (dual specificity phosphatase 2)|
|Background|| The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq]|
|Synonyms||PAC-1 antibody, PAC1 antibody, DUSP2 antibody, serine/threonine specific protein phosphatase antibody, dual specificity protein phosphatase 2 antibody, dual specificity protein phosphatase PAC-1 antibody, dual-specificity phosphatase 2 antibody, dual specificity phosphatase 2 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DUSP2/PAC1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (100%)|