|Full Name||dual specificity phosphatase 3|
|Product Description||Rabbit Polyclonal antibody to DUSP3 (dual specificity phosphatase 3)|
|Background||The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]|
|Synonyms||VHR antibody, DUSP3 antibody, vaccinia H1-related phosphatase antibody, serine/threonine specific protein phosphatase antibody, dual specificity protein phosphatase 3 antibody, dual specificity protein phosphatase VHR antibody, vaccinia virus phosphatase VH1-related antibody, dual specificity phosphatase 3 antibody|
|Immunogen||Full length human DUSP3 Recombinant protein.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (91%), Rhesus Monkey (100%), Bovine (97%)|