|Full Name||dual specificity phosphatase 6|
|Product Description||Rabbit polyclonal antibody to MKP-3 (dual specificity phosphatase 6)|
|Background||The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||MKP3 antibody, PYST1 antibody, DUSP6 antibody, dual specificity protein phosphatase 6 antibody, serine/threonine specific protein phosphatase antibody, MAP kinase phosphatase 3 antibody, mitogen-activated protein kinase phosphatase 3 antibody, dual specificity protein phosphatase PYST1 antibody, dual specificity phosphatase 6 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DUSP6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (99%), Zebrafish (89%), Xenopus laevis (92%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%)|