|Full Name||dual specificity phosphatase 8|
|Product Description||Rabbit Polyclonal antibody to DUSP8 (dual specificity phosphatase 8)|
|Background||The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq]|
|Synonyms||C11orf81 antibody, FLJ42476 antibody, FLJ42958 antibody, HB5 antibody, HVH-5 antibody, HVH8 antibody, DUSP8 antibody, serine/threonine specific protein phosphatase antibody, "H1 phosphatase, vaccinia virus homolog antibody", dual specificity protein phosphatase 8 antibody, dual specificity protein phosphatase hVH-5 antibody, dual specificity phosphatase 8 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human DUSP8. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (100%), Rat (100%)|