|Full Name||deoxyuridine triphosphatase|
|Product Description||Rabbit Polyclonal antibody to DUT (deoxyuridine triphosphatase)|
|Background||This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq]|
|Synonyms||FLJ20622 antibody, dUTPase antibody, DUT antibody, dUTP nucleotidohydrolase antibody, "deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial antibody", dUTP pyrophosphatase antibody, deoxyuridine triphosphatase antibody|
|Cellular Localization||Mitochondrion , Nucleus|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human DUT. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Bovine|
|Predict Reactivity Note||Mouse (85%), Rat (85%), Chicken (83%), Bovine (87%)|