|Full Name||dachshund homolog 1 (Drosophila)|
|Product Description||Goat polyclonal antibody to DACH1|
|Background||Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain. |
|Synonyms||DACH, Dachshund homolog1, dachshund homolog 1, dachshund homolog1 (Drosophila), FLJ10138, RP11512J14.1, dachshund homolog 1 (Drosophila), RP11-512J14.1, DACH1, OTTHUMP00000040839|
|Specificity||This antibody is specific for DACH1.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig|