Dbs antibody [N1N2], N-term
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||128 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||MCF.2 cell line derived transforming sequence-like|
|Product Description||Rabbit polyclonal antibody to DBS (MCF.2 cell line derived transforming sequence-like)|
|Background||Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.|
|Synonyms||ARHGEF14 antibody, DBS antibody, FLJ12122 antibody, KIAA0362 antibody, OST antibody, MCF2L antibody, DBL's big sister antibody, guanine nucleotide exchange factor DBS antibody, MCF2 transforming sequence-like protein antibody, MCF.2 cell line derived transforming sequence-like antibody|
|Cellular Localization||Cytoplasm (By similarity) , Cell membrane; Peripheral membrane protein; Cytoplasmic side |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human Dbs. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (90%), Rat (89%)|