| Full Name | desmoplakin |
| Background | Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008] |
| Synonyms | DSP Antibody , DPI Antibody , DPII Antibody , DCWHKTA Antibody , desmoplakin Antibody , DP Antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide of human DSP |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |
| Conjugation | Unconjugated |