Desmoplakin antibody

Cat No:

GTX32557

Package	Price	Qty
100 μl	USD 319.00

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Catalog Number

GTX32557

Product Name

Desmoplakin antibody

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Applications

IHC-P, WB

Application Note

	Suggested dilution	Reference
IHC (Formalin-fixed paraffin-embedded sections)	1:50 - 1:200*	Y
Western Blot (WB)	1:500 - 1:2000*

Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.

Predicted Target Size

332 kDa (note)

Form Supplied

Liquid

Purification

Purified by affinity chromatography

Full Name	desmoplakin
Background	Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
Synonyms	DSP Antibody , DPII Antibody , DPI Antibody , DP Antibody
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DSP (NP_004406.2).
Antigen Species	Human
Species Reactivity	Human, Mouse
Conjugation	Unconjugated

Storage Buffer	PBS pH7.3, 0.02% sodium azide, 50% glycerol.
Storage Instruction	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Notes	For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Desmoplakin antibody validated data

Application References	Application	Reactivity
Wang Y et al. Osteoprotegerin deficiency causes morphological and quantitative damage in epithelial rests of Malassez. J Mol Histol (Epub ahead of print) (2018).	IHC-P	Mouse

Primary Antibodies