|Product Description||Rabbit polyclonal antibody to Doublecortin (doublecortex; lissencephaly, X-linked (doublecortin))|
|Background||In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DBCN antibody, DC antibody, FLJ51296 antibody, LISX antibody, SCLH antibody, XLIS antibody, DCX antibody, lissencephalin-X antibody, doublin antibody, lis-X antibody, neuronal migration protein doublecortin antibody, doublecortex antibody, doublecortin antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Doublecortin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (100%), Chicken (94%), Bovine (99%)|