|Full Name||cadherin 1, type 1, E-cadherin (epithelial)|
|Product Description||Mouse Monoclonal antibody [GT477] to E-Cadherin (cadherin 1, type 1, E-cadherin (epithelial))|
|Background||This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq]|
|Cellular Localization||Cell junction , Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human E-Cadherin. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig, Bovine|
|Predict Reactivity Note||Mouse (80%), Rat (83%), Dog (80%), Pig (83%), Bovine (82%)|