|Full Name||E2F transcription factor 3|
|Product Description||Rabbit Polyclonal antibody to E2F3 (E2F transcription factor 3)|
|Background||The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]|
|Synonyms||DKFZp686C18211 antibody, E2F-3 antibody, KIAA0075 antibody, MGC104598 antibody, E2F3 antibody, transcription factor E2F3 antibody, E2F transcription factor 3 antibody|
|Specificity||Knockdown/Knockout validation was supported by customer review data.|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human E2F3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (98%), Xenopus laevis (81%), Bovine (98%)|