|Full Name||E2F transcription factor 6|
|Product Description||Rabbit Polyclonal antibody to E2F6 (transcription factor E2F6)|
|Background||This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq]|
|Synonyms||E2F-6 antibody, MGC111545 antibody, E2F6 antibody, transcription factor E2F6 antibody, "E2F transcription factor 6, isoform 1 antibody", E2F transcription factor 6 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human E2F6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (80%), Rat (80%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (92%)|