|Full Name||ER degradation enhancer, mannosidase alpha-like 1|
|Product Description||Rabbit Polyclonal antibody to EDEM1 (ER degradation enhancer, mannosidase alpha-like 1)|
|Background||Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity. |
|Synonyms||EDEM Antibody , ER degradation enhancer, mannosidase alpha-like 1 Antibody|
|Cellular Localization||Endoplasmic reticulum membrane |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human EDEM1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (87%), Rat (87%), Rhesus Monkey (100%), Bovine (92%)|