|Full Name||eukaryotic translation initiation factor 6|
|Product Description||Rabbit Polyclonal antibody to EIF6 (eukaryotic translation initiation factor 6)|
|Background||Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CAB antibody, EIF3A antibody, ITGB4BP antibody, b(2)gcn antibody, eIF-6 antibody, p27(BBP) antibody, p27BBP antibody, EIF6 antibody, eukaryotic translation initiation factor 3A antibody, eukaryotic translation initiation factor 6 antibody, p27 beta-4 integrin-binding protein antibody, B4 integrin interactor antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human EIF6. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Drosophila, Xenopus laevis, Pig, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (92%), Drosophila (82%), Xenopus laevis (91%), Pig (98%), Chicken (94%), Sheep (99%), Bovine (97%)|