|Full Name||excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)|
|Product Description||Rabbit polyclonal antibody to ERCC1 (excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence))|
|Background||The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq]|
|Synonyms||COFS4 antibody, RAD10 antibody, UV20 antibody, ERCC1 antibody, DNA excision repair protein ERCC-1 antibody, "excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ERCC1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (93%), Pig (95%), Chimpanzee (100%), Bovine (96%)|