|Full Name||excision repair cross-complementing rodent repair deficiency, complementation group 2|
|Product Description||Rabbit Polyclonal antibody to ERCC2 (TFIIH basal transcription factor complex helicase XPD subunit)|
|Background||The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||COFS2 antibody, EM9 antibody, MGC102762 antibody, MGC126218 antibody, MGC126219 antibody, TTD antibody, XPD antibody, ERCC2 antibody, basic transcription factor 2 80 kDa subunit antibody, TFIIH p80 antibody, TFIIH basal transcription factor complex helicase subunit antibody, xeroderma pigmentosum complementary group D antibody, TFIIH basal transcription factor complex 80 kDa subunit antibody, TFIIH basal transcription factor complex helicase XPD subunit antibody, DNA excision repair protein ERCC-2 antibody, CXPD antibody, xeroderma pigmentosum group D-complementing protein antibody, BTF2 p80 antibody, DNA repair protein complementing XP-D cells antibody, TFIIH 80 kDa subunit antibody, "excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody"|
|Cellular Localization||Nucleus. Cytoplasm ? cytoskeleton ? spindle|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ERCC2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Chimpanzee (99%), Bovine (96%)|