|Full Name||excision repair cross-complementing rodent repair deficiency, complementation group 2|
|Product Description||Rabbit Polyclonal antibody to ERCC2 (excision repair cross-complementing rodent repair deficiency, complementation group 2)|
|Background||The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||COFS2 Antibody , excision repair cross-complementing rodent repair deficiency, complementation group 2 Antibody , ERCC2 Antibody , EM9 Antibody , TTD Antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ERCC2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Zebrafish (86%), Chimpanzee (99%), Bovine (98%)|