| Full Name | excision repair cross-complementing rodent repair deficiency, complementation group 2 |
| Background | The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Synonyms | COFS2 Antibody , excision repair cross-complementing rodent repair deficiency, complementation group 2 Antibody , ERCC2 Antibody , EM9 Antibody , TTD Antibody |
| Cellular Localization | Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human ERCC2. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Mouse, Rat, Zebrafish, Chimpanzee, Bovine |
| Predict Reactivity Note | Mouse (97%), Rat (97%), Zebrafish (86%), Chimpanzee (99%), Bovine (98%) |
| Conjugation | Unconjugated |