|Full Name||ERO1-like (S. cerevisiae)|
|Product Description||Rabbit Polyclonal antibody to ERO1L (ERO1-like (S. cerevisiae))|
|Background||Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. |
|Synonyms||ERO1-alpha antibody, ERO1A antibody, ERO1L antibody, ERO1-like protein alpha antibody, oxidoreductin-1-L-alpha antibody, ERO1-L antibody, endoplasmic oxidoreductin-1-like protein antibody, ERO1-L-alpha antibody, ERO1-like (S. cerevisiae) antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ERO1L. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (90%), Pig (96%), Rhesus Monkey (99%), Bovine (96%)|