ESE1 antibody [C2C3], C-term
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||41 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||E74-like factor 3 (ets domain transcription factor, epithelial-specific )|
|Product Description||Rabbit polyclonal antibody to ESE1 (E74-like factor 3 (ets domain transcription factor, epithelial-specific ))|
|Background||Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. |
|Synonyms||EPR-1 antibody, ERT antibody, ESE-1 antibody, ESX antibody, ELF3 antibody, "ets domain transcription factor, serine box (epithelial-specific) antibody", "E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific) antibody", epithelium-restricted Ets protein ESX antibody, E74-like factor 3 (ets domain transcription factor) antibody, epithelial-restricted with serine box antibody, ETS-related transcription factor Elf-3 antibody, epithelium-specific Ets transcription factor 1 antibody, "E74-like factor 3 (ets domain transcription factor, epithelial-specific ) antibody"|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ESE1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (85%)|