|Full Name||enhancer of zeste homolog 1 (Drosophila)|
|Product Description||Goat polyclonal antibody to EZH1|
|Background||Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
|Synonyms||enhancer of zeste homolog1 (Drosophila), KIAA0388, EZH1, enhancer of zeste homolog 1 (Drosophila), KMT6B|
|Cellular Localization||Colocalizes with trimethylated 'Lys-27' of histone H3. |
|Specificity||This antibody is specific for EZH1.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.