|Full Name||endothelin receptor type B|
|Product Description||Rabbit Polyclonal antibody to Endothelin B Receptor (endothelin receptor type B)|
|Background||The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq]|
|Synonyms||ABCDS antibody, ETB antibody, ETBR antibody, ETRB antibody, HSCR antibody, HSCR2 antibody, WS4A antibody, EDNRB antibody, endothelin receptor non-selective type antibody, endothelin B receptor antibody, endothelin receptor type B antibody|
|Cellular Localization||Cell membrane |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Endothelin B Receptor. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Pig, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Mouse (100%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (100%), Bovine (100%)|