|Full Name||suppressor of Ty 16 homolog (S. cerevisiae)|
|Product Description||Goat polyclonal antibody to FACT / SUPT16H|
|Background||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. |
|Synonyms||HGNC:11465, FACT, chromatin-specific transcription elongation factor large subunit, FACTP140, FLJ34357, facilitates chromatin remodeling 140 kDa subunit, FLJ10857, facilitates chromatin remodeling140 kDa subunit, SUPT16H, chromatinspecific transcription elongation factor large subunit, CDC68, SPT16/CDC68, FACT / SUPT16H, chromatinspecific transcription elongation factor la, FLJ14010|
|Cellular Localization||Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. |
|Specificity||This antibody is specific for FACT / SUPT16H.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Bovine|