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Catalog Number
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GTX110546-pro
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0
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Product Name
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FADD Protein
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| Full Name | Fas (TNFRSF6)-associated via death domain |
| Synonyms | MGC8528, MORT1, FADD, mediator of receptor induced toxicity, protein FADD, Fas-associating protein with death domain, growth-inhibiting gene 3 protein, mediator of receptor-induced toxicity, Fas-associating death domain-containing protein, Fas (TNFRSF6)-associated via death domain |
| Background | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq] |
| Species | Human |
| Expression System | E. coli |
| Applications | WB |
| Predicted Target Size(KDa) | 23 Kda(note) |
| Purification | Purified by conventional chromatography. |
| Purity | 90% |
| Storage Buffer | 0.1%SDS/PBS |
| Storage Instruction | Keep as concentrated solution. For extended storage add 50% glycerol, aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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