| Full Name | PTK2 protein tyrosine kinase 2 |
| Background | Focal Adhesion Kinase is a non-receptor protein tyrosine kinase discovered as a substrate for Src and as a key element of integrin signalling. Focal Adhesion Kinase plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. The activity of the phosphorylation site pTyr407 is currently unknown. |
| Synonyms | pp125FAK, 5747, PTK2, FAK, FAK1, Q05397, 600758, FADK, FAK (phospho Y407), FAK (phospho Tyr407), FAK (pY407), FAK (pTyr407), FAK phospho Y407, FAK phospho Tyr407, Phospho FAK (Y407), Phospho FAK (Tyr407), Phospho FAK (pY407), Phospho FAK (pTyr407) |
| Cellular Localization | Cytoplasmic, localized to focal adhesions. |
| Specificity | Phosphorylation site-specific antibody selective for the phosphorylated form of the Focal Adhesion Kinase enzyme containing a phosphate on tyrosine 407. The antibody has been shown to recognize Focal Adhesion Kinase (approximately 125 kDa) in chick embryo fibroblast cells plated on fibronectin. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Synthetic peptide derived from the region of Focal Adhesion Kinase that contains tyrosine 407. The sequence is conserved in human, mouse, rat, chicken and frog. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |