FDPS antibody [N1C3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||48 kDa (note)
|Positive Controls||A549 , HeLa , HepG2 , HCT116 , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||farnesyl diphosphate synthase|
|Product Description||Rabbit Polyclonal antibody to FDPS (farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase))|
|Background||This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||FPPS antibody, FPS antibody, FDPS antibody, farnesyl pyrophosphate synthase antibody, geranyltranstransferase antibody, "(2E,6E)-farnesyl diphosphate synthase antibody", FPP synthase antibody, dimethylallyltranstransferase antibody, FPP synthetase antibody, "farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase antibody", farnesyl diphosphate synthase antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FDPS. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (89%), Pig (89%), Bovine (91%)|