|Full Name||leucine zipper, putative tumor suppressor 1|
|Product Description||Rabbit Polyclonal antibody to FEZ1 (leucine zipper, putative tumor suppressor 1)|
|Background||This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq]|
|Synonyms||F37 antibody, FEZ1 antibody, LZTS1 antibody, F37/Esophageal cancer-related gene-coding leucine-zipper motif antibody, leucine zipper putative tumor suppressor 1 antibody, "leucine zipper, putative tumor suppressor 1 antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Cell membrane (By similarity) , Cell projection , dendritic spine (By similarity) , Cell junction , synapse , postsynaptic cell membrane , postsynaptic density (By similarity) , synapse (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FEZ1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (89%), Rat (92%), Bovine (90%)|