|Full Name||FYVE, RhoGEF and PH domain containing 1|
|Product Description||Rabbit polyclonal antibody to FGD1 (FYVE, RhoGEF and PH domain containing 1)|
|Background||FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. [provided by RefSeq]|
|Synonyms||AAS antibody, FGDY antibody, MRXS16 antibody, ZFYVE3 antibody, FGD1 antibody, zinc finger FYVE domain-containing protein 3 antibody, rho/Rac GEF antibody, "FYVE, RhoGEF and PH domain-containing protein 1 antibody", rho/Rac guanine nucleotide exchange factor FGD1 antibody, faciogenital dysplasia 1 protein antibody, "FYVE, RhoGEF and PH domain containing 1 antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Cell projection , lamellipodium (By similarity) , ruffle (By similarity) , Cytoplasm , cytoskeleton (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human FGD1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Bovine (100%)|