FGD4 antibody [N1N3]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||87 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||FYVE, RhoGEF and PH domain containing 4|
|Product Description||Rabbit polyclonal antibody to FGD4 (FYVE, RhoGEF and PH domain containing 4)|
|Background||This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq]|
|Synonyms||CMT4H antibody, DKFZp313E1818 antibody, DKFZp434K1572 antibody, FLJ34370 antibody, FLJ42663 antibody, FRABP antibody, MGC57222 antibody, ZFYVE6 antibody, FGD4 antibody, "FYVE, RhoGEF and PH domain-containing protein 4 antibody", FGD1-related F-actin-binding protein antibody, "FGD1 family, member 4 antibody", actin-filament binding protein frabin antibody, actin filament-binding protein frabin antibody, zinc finger FYVE domain-containing protein 6 antibody, "FYVE, RhoGEF and PH domain containing 4 antibody"|
|Cellular Localization||Cytoplasm , cytoskeleton (By similarity) , Cell projection , filopodium (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FGD4. The exact sequence is proprietary.|