Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||92 kDa (note)
|Positive Controls||SHSY5Y , 293T , A431 , A375 , H1299 , HCT116 , HeLa , Molt-4 , U87-MG , SK-N-SH , IMR32 , SK-N-AS , A549 , Mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||fibroblast growth factor receptor 1|
|Product Description||Rabbit Polyclonal antibody to FGFR1 (fibroblast growth factor receptor 1)|
|Background||The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]|
|Synonyms||BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FLG antibody, FLJ99988 antibody, FLT2 antibody, HBGFR antibody, KAL2 antibody, N-SAM antibody, OGD antibody, FGFR1 antibody, heparin-binding growth factor receptor antibody, hydroxyaryl-protein kinase antibody, proto-oncogene c-Fgr antibody, FMS-like tyrosine kinase 2 antibody, fms-related tyrosine kinase 2 antibody, FGFR1/PLAG1 fusion antibody, fibroblast growth factor receptor 1 antibody, basic fibroblast growth factor receptor 1 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FGFR1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Chicken, Bovine|
|Predict Reactivity Note||Rat (97%), Chicken (90%), Bovine (97%)|