|Full Name||fibroblast growth factor receptor 2|
|Product Description||Rabbit Polyclonal antibody to FGFR2 (fibroblast growth factor receptor 2)|
|Background||The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]|
|Synonyms||BEK antibody, BFR-1 antibody, CD332 antibody, CEK3 antibody, CFD1 antibody, ECT1 antibody, FLJ98662 antibody, JWS antibody, K-SAM antibody, KGFR antibody, TK14 antibody, TK25 antibody, FGFR2 antibody, fibroblast growth factor receptor 2 antibody, FGFR-2 antibody, hydroxyaryl-protein kinase antibody, bacteria-expressed kinase antibody, "protein tyrosine kinase, receptor like 14 antibody", FGF receptor antibody, soluble FGFR4 variant 4 antibody, BEK fibroblast growth factor receptor antibody, keratinocyte growth factor receptor antibody|
|Cellular Localization||Cell membrane; Single-pass type I membrane protein , Isoform 14: Secreted , Isoform 19: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human FGFR2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Dog, Pig, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (98%), Zebrafish (89%), Xenopus laevis (90%), Dog (99%), Pig (97%), Rabbit (84%), Chicken (97%), Bovine (98%)|