Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||52 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , A375 , GL261 , C8D30 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||FK506 binding protein 4, 59kDa|
|Product Description||Rabbit Polyclonal antibody to FKBP4 (FK506 binding protein 4, 59kDa)|
|Background||The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq]|
|Synonyms||FKBP51 antibody, FKBP52 antibody, FKBP59 antibody, HBI antibody, Hsp56 antibody, PPIase antibody, p52 antibody, FKBP4 antibody, FK506-binding protein 4 (59kD) antibody, T-cell FK506-binding protein, 59kD antibody, peptidylprolyl cis-trans isomerase antibody, HSP binding immunophilin antibody, peptidyl-prolyl cis-trans isomerase FKBP4 antibody, rotamase antibody, 51 kDa FK506-binding protein antibody, FK506 binding protein 4, 59kDa antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FKBP4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Pig, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Pig (97%), Rabbit (93%), Chicken (85%), Rhesus Monkey (98%), Bovine (95%)|