|Full Name||arachidonate 5-lipoxygenase-activating protein|
|Product Description||Rabbit Polyclonal antibody to FLAP (arachidonate 5-lipoxygenase-activating protein)|
|Background||This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. [provided by RefSeq]|
|Synonyms||arachidonate 5-lipoxygenase-activating protein Antibody, ALOX5AP Antibody|
|Cellular Localization||Nucleus membrane , Endoplasmic reticulum membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human FLAP. The exact sequence is proprietary.|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Pig (91%), Chicken (81%), Rhesus Monkey (97%), Bovine (89%)|