| Full Name | caspase 8 associated protein 2 |
| Product Description | Rabbit polyclonal to FLASH |
| Background | A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). |
| Synonyms | CASP8AP2, KIAA1315, 606880, CED-4, CED4, FLASH, Q9UKL3, RIP25, FLJ11208, 9994, CED 4 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | FLASH |
| Isotype | IgG |
| Immunogen | 1221~1270a.a of human FLASH(AAD45157). This sequence differs by one amino acid from that of mouse. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse |