|Full Name||furin (paired basic amino acid cleaving enzyme)|
|Product Description||Rabbit polyclonal antibody to FURIN (furin (paired basic amino acid cleaving enzyme))|
|Background||The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]|
|Synonyms||FUR antibody, PACE antibody, PCSK3 antibody, SPC1 antibody, FURIN antibody, FES upstream region antibody, "furin, membrane associated receptor protein antibody", paired basic amino acid residue-cleaving enzyme antibody, proprotein convertase subtilisin/kexin type 3 antibody, dibasic-processing enzyme antibody, dibasic processing enzyme antibody, furin (paired basic amino acid cleaving enzyme) antibody|
|Cellular Localization||Golgi apparatus , trans-Golgi network membrane; Single-pass type I membrane protein , Cell membrane; Single-pass type I membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FURIN. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (100%), Rat (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)|