|Full Name||coagulation factor VII (serum prothrombin conversion accelerator)|
|Product Description||Rabbit polyclonal antibody to Factor VII (coagulation factor VII (serum prothrombin conversion accelerator))|
|Background||This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq]|
|Synonyms||F7 antibody, SPCA antibody, proconvertin antibody, FVII coagulation protein antibody, coagulation factor VII antibody, eptacog alfa antibody, serum prothrombin conversion accelerator antibody, coagulation factor VII (serum prothrombin conversion accelerator) antibody|
|Specificity||Upon activation of the factor VII, proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts Factor VII (FVII) to an activated two-chain form (FVIIa). A heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated. Since the immunogen sequence locates within the heavy chain, it should recognize both Factor VII and Factor VIIa.|
|Target||Factor VII |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Factor VII. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (91%)|