|Full Name||coagulation factor X|
|Product Description||Rabbit Polyclonal antibody to Factor X (coagulation factor X)|
|Background||This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq]|
|Synonyms||FX antibody, FXA antibody, F10 antibody, Stuart-Prower factor antibody, prothrombinase antibody, coagulation factor X antibody, factor Xa antibody|
|Cellular Localization||Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Factor X. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rabbit, Rhesus Monkey|
|Predict Reactivity Note||Rabbit (81%), Rhesus Monkey (95%)|