|Full Name||coagulation factor XIII, A1 polypeptide|
|Product Description||Rabbit polyclonal antibody to Factor XIIIa (coagulation factor XIII, A1 polypeptide)|
|Background||This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]|
|Synonyms||F13A antibody, F13A1 antibody, protein-glutamine gamma-glutamyltransferase A chain antibody, fibrinoligase antibody, TGase antibody, "FSF, A subunit antibody", coagulation factor XIIIa antibody, transglutaminase A chain antibody, "fibrin stabilizing factor, A subunit antibody", transglutaminase. plasma antibody, "bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody", "coagulation factor XIII, A polypeptide antibody", factor XIIIa antibody, coagulation factor XIII A chain antibody, "coagulation factor XIII, A1 polypeptide antibody"|
|Cellular Localization||Cytoplasm , Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human Factor XIIIa. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (84%), Bovine (86%)|