Fas Ligand antibody [10F2] (Low endotoxin, azide free)
|Applications||ELISA, FACS, IP, Functional Assay|
| ELISA||Assay-dependent dilution
| Immunoprecipitation||Assay-dependent dilution
| Functional Assay||Assay-dependent dilution
Flow cytometry/FACS : Use 10μl of the suggested working dilution to label 106 cells in 100μl.Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
(Please refer to the vial label for the specific concentration)|
|Purification||Protein G purified|
|Purification Note||From tissue culture supernatant|
|Full Name||Fas ligand|
|Product Description||Mouse monoclonal antibody [10F2] to Fas Ligand|
|Background||This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]|
|Synonyms||ALPS1B Antibody , FASL Antibody , CD95L Antibody , APT1LG1 Antibody , CD95-L Antibody , CD178 Antibody , APTL Antibody , FASLG Antibody , TNFSF6 Antibody|
|Specificity||This antibody recognizes the human CD178 cell surface antigen, a 40kDa glycoprotein also known as Fas ligand (CD95L). Clone 10F2 is reported to block the activity of Fas ligand (Legembre et al. 2002).|