|Product Description||Rabbit Polyclonal antibody to Fibrillarin (fibrillarin)|
|Background||This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq]|
|Synonyms||FIB antibody, FLRN antibody, RNU3IP1 antibody, FBL antibody, 34 kDa nucleolar scleroderma antigen antibody, RNA, U3 small nucleolar interacting protein 1 antibody, rRNA 2'-O-methyltransferase fibrillarin antibody, 34-kD nucleolar scleroderma antigen antibody, fibrillarin antibody|
|Cellular Localization||Nucleus , nucleolus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Fibrillarin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Zebrafish (80%), Bovine (98%)|